Multi-layer Microfluidic Devices for Amino Acid Analysis: the Mars Organic Analyzer
نویسندگان
چکیده
Sensitive amino acid composition and chirality analysis is demonstrated using the Mars Organic Analyzer (MOA), a portable microfabricated capillary electrophoresis (CE) instrument. The MOA integrates all high voltage power supplie s, pneumatic controls, and fluorescence detection optics. The microfabricated device is a novel multi-layer structure combining glass separation channels [1] and microfabricated pneumatic membrane valves and pumps [2]. The Mars Organic Analyzer has been successfully field tested demonstrating part-per-trillion sensitivity when analyzing jarosite, a key sulfate-rich mineral recently detected on Mars that is associated with liquid water [3].
منابع مشابه
Mars Organic Detector III: A Versatile Instrument for Detection of Bio-organic Signatures on Mars
Recent advances in the development of microfabricated lab-on-a-chip analysis systems have enhanced the feasibility and capabilities of in situ chemical and biochemical analyzers. While a wide variety of bio-organic molecules can be probed, we have focused our initial studies on the development of an amino acid analyzer with the hypothesis that extraterrestrial life would be based on homochiral ...
متن کاملCapillary electrophoresis analysis of organic amines and amino acids in saline and acidic samples using the Mars organic analyzer.
The Mars Organic Analyzer (MOA) has enabled the sensitive detection of amino acid and amine biomarkers in laboratory standards and in a variety of field sample tests. However, the MOA is challenged when samples are extremely acidic and saline or contain polyvalent cations. Here, we have optimized the MOA analysis, sample labeling, and sample dilution buffers to handle such challenging samples m...
متن کاملDevelopment and evaluation of a microdevice for amino acid biomarker detection and analysis on Mars.
The Mars Organic Analyzer (MOA), a microfabricated capillary electrophoresis (CE) instrument for sensitive amino acid biomarker analysis, has been developed and evaluated. The microdevice consists of a four-wafer sandwich combining glass CE separation channels, microfabricated pneumatic membrane valves and pumps, and a nanoliter fluidic network. The portable MOA instrument integrates high volta...
متن کاملPolycyclic aromatic hydrocarbon analysis with the Mars organic analyzer microchip capillary electrophoresis system.
The Mars Organic Analyzer (MOA), a portable microchip capillary electrophoresis (CE) instrument developed for sensitive amino acid analysis on Mars, is used to analyze laboratory standards and real-world samples for polycyclic aromatic hydrocarbons (PAHs). The microfabricated CE separation and analysis method for these hydrophobic analytes is optimized, resulting in a separation buffer consisti...
متن کاملOrganic amine biomarker detection in the Yungay region of the Atacama Desert with the Urey instrument
[1] The Urey in situ organic compound analysis instrument, consisting of a subcritical water extractor (SCWE) and a portable microchip capillary electrophoresis instrument called the Mars Organic Analyzer (MOA), was field tested in the Atacama Desert, Chile, in June 2005. Soil samples from the most arid Yungay region were collected, biomarkers were extracted by the SCWE, and organic amine compo...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2004